When the hit-man Chev Chelios is poisoned by the criminal Verona, his friend and doctor Miles advises him that he must keep his adrenaline levels elevated to stay alive. Chev meets his girlfriend Eve and together they look for Verona to kill him.
CRANK 2: High Voltage
Chev Chelios survives a fall from the sky, sort of. He's in an unknown location, sedated, while various Chinese are harvesting his organs. His heart is gone, in an ice chest; a temporary in its place. Chev escapes, knowing only the name of the guy with the ice chest. He calls Doc Miles, an unlicensed cardiologist, who tells him there's only an hour's life in the artificial heart: keep it charged. Chev needs to find his own heart and get to Doc for a transplant. He starts his time-limited pursuit of shadowy figures, the ice chest, and his heart aided by Eve, Rei, and Venus - a stripper, a prostitute, and a pal with Tourette's - constantly needing an electric charge to keep going.
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